One of the most celebrated luxury properties in Ecuador, Casa Gangotena occupies the site of former presidential mansions, and the aesthetic is appropriately posh: Art Deco and Art Nouveau design elements are prominent throughout the property, including hand-painted murals and friezes, crystal chandeliers, restored tin ceilings, and Egyptian and Statuarietto marbles throughout the property.

This plush hotel opened its doors in 2017 and offers a unique cultural experience for guests. Located in the creative San Marcos neighborhood, home to artists, writers and musicians.

Behind oversized copper-clad doors is a sleek, contemporary property with buzzy public spaces like a chic lounge and lively rooftop. Rooms, meanwhile, all have separate sleeping and lounging areas, and deep soaking tubs.

A boutique property in a converted historic home, the heart of Quito’s colonial center, Hotel Patio Andaluz centers around a grand, glass-covered atrium with a charming courtyard restaurant on the ground floor. Elegant rooms feature dark wood furnishings and antiques.

Modern, comfortable rooms with a number of amenities—free high-speed Wi-Fi, flat-screen TVs, an iPod docking station — guests at the Wyndham will enjoy this sleek and convenient place to bed down near the international airport.